منابع مشابه
Acute lymphocytic leukemia with variant t(5;14) and preleukemia: expanding the spectrum of the 5q- abnormality?
In the July 15, 1990 issue, Meeker et all described the molecular events underlying the (5;14)(q31;q32) translocation that occurs in acute lymphocytic leukemia (ALL) of B-lineage associated with eosinophilia. Observations of specific chromosomal translocations such as the t(5;14), which are associated with hematopoetic malignancies displaying a unique biologic or clinical characteristic, are im...
متن کاملThe 5q- syndrome.
The 5q- syndrome is a distinct hematological disorder with typical laboratory, morphological, cytogenetic, molecular, and prognostic features. It is defined as a myelodysplastic syndrome with a medullary blast count <5% and an isolated interstitial deletion of the long arm of chromosome 5, including bands q31-q33. The molecular basis of this disease has not yet been fully elucidated, but there ...
متن کاملAdvances in the 5q- syndrome.
The 5q- syndrome is the most distinct of all the myelodysplastic syndromes with a clear genotype/phenotype relationship. The significant progress made during recent years has been based on the determination of the commonly deleted region and the demonstration of haploinsufficiency for the ribosomal gene RPS14. The functional screening of all the genes in the commonly deleted region determined t...
متن کاملTreatment of the 5q- syndrome.
Defined by isolated del 5q and no excess of marrow blasts, the "5q- syndrome" is a specific type of myelodysplastic syndrome (MDS) with particular characteristics, including severe anemia, frequent thrombocytosis, typical dysmegakaryopoiesis and favorable outcome. Its pathogenesis remains uncertain, in particular the role of inactivation of gene(s) situated in 5q. It should be differentiated fr...
متن کاملChromosomal abnormality of acute promyelocytic leukemia other than PML-RARA: a case report of acute promyelocytic leukemia with del(5q)
BACKGROUND The recent study described a better outcome in acute promyelocytic leukemia patients treated with all-trans retinoic acid and arsenic oxide compared to those treated with all-trans retinoic acid combined with conventional chemotherapy. The pivotal study indicated that favorable-risk acute promyelocytic leukemia patients can be cured without any cytotoxic chemotherapy. Even high-risk ...
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ژورنال
عنوان ژورنال: Blood
سال: 1987
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v70.6.1705.bloodjournal7061705